Glutamate is the primary excitatory neurotransmitter of the central nervous system. Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate rapid excitatory neurotransmission in the CNS. Dysfunctional neurotransmission through iGluRs contributes to the pathophysiology of many psychiatric and neurological disorders. A central goal of the Jones Lab is to identify novel therapeutics to improve iGluR dysfunction in mental health disorders. We have ongoing projects to:

1) Elucidate the neurobiological mechanisms of drug-induced psychosis
2) Characterize the molecular mechanisms of ketamine-mediated rapid anti-depression
3) Identify novel small molecules for the treatment of PTSD